Effect of electroacupuncture on ischemic neuronal apoptosis in striate body and adjustment of gene expression 电针对脑纹状体缺血性神经元细胞凋亡及基因表达的调整
After the left black substance was destroyed by stereotaxic technigue with 6-OHDA, the rat was given continually medicine for four days, then killed, taking out the black substance and striate body; MDA, T-SOD, GSH, GSH-PX were measured. 给大鼠平颤汤灌胃4d,用6-OHDA立体定向损毁左侧黑质,继续给药4d后处死,取黑质和纹状体,测定MDA、T-SOD、GSH、GSH-PX;
Methods: Multiple cerebral infarction was induced by injecting embolus through external carotid artery. Memory-detection model of anisodamine was established to determine the histopathology of cerebral cortex, hypothalamus, hippocampus and striate body of rats. 从颈外动脉注射栓子造成多发性脑梗塞,加注山莨菪碱,以记忆力检测模型,测量各组大鼠脑内皮层、下丘脑、海马、纹状体部的病理组织学。
AIM: To observe the effect of electroacupuncture ( EA) on the neuronal injury and apoptosis morphology of striate body in rats with cerebral ischemia, and explore the possible molecular biological mechanism of EA in the protection of anti-oxidative stress. 目的:观察电针对脑纹状体缺血性神经元损伤细胞凋亡形态学及基因表达的影响,探索电针对其抗氧应激保护作用可能的分子生物学机制。
Dopamine ( DA) contents of frontal cortex, striate body and hypothalamus tissues were assayed by using high performance liquid chromatography electro-chemical detection technique. 采用高效液相-电化学法测定部分脑区多巴胺(DA)含量。
Objective: To observe the effects of dihydroergotoxine on parkinsonism model mice including their behavior, activity of brain SOD, and the contents of dopamine and derivatives in striate body. 目的:观察二氢麦角毒对1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)帕金森病模型小鼠行为学、脑超氧化物歧化酶(SOD)活性及纹状体多巴胺及其代谢产物含量的影响。
Results Compared with model group, the behaviors of rats in acupuncture group were significantly improved ( P < 0.01). The content of DA, HVA and DOPAC in striate body of rats with PD in acupuncture group were increased significantly ( P < 0.01). 结果与模型组比较,针刺后PD大鼠行为学明显改善(P<0.01),同时针刺组大鼠纹状体DA及代谢产物的含量均显著增加(P<0.01)。
Results Integrative Chinese-Western medication could elevate the TH contents, increase the TH activity, and alleviate or prevent 6-OHDA from damaging the black substance and striate body; 结果中西药合用可以升高TH的含量,提高TH的活力,阻止或缓解6-OHDA对黑质及纹状体的损毁作用;
The Effect of Acupuncture on the Content of Dopamine, HVA and DOPAC in Striate Body of Rats with Parkinson's Disease 针刺对帕金森模型大鼠纹状体多巴胺及代谢产物含量的影响
Results: INOS positive cells of endotoxin group distributed over cerebral cortex, striate body, brain stem and cerebellum etc. 结果:内毒素组iNOS阳性细胞分布于大脑皮质、纹状体、脑干、小脑等。